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. 1998 Jul 7;8(13):1745-50.
doi: 10.1016/s0960-894x(98)00308-4.

Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

D G Batt  1 , J J Petraitis, S R Sherk, R A Copeland, R L Dowling, T L Taylor, E A Jones, R L Magolda, B D Jaffee
Affiliations

Heteroatom- and carbon-linked biphenyl analogs of Brequinar as immunosuppressive agents

D G Batt et al. Bioorg Med Chem Lett. .

Abstract

Structure-activity relationships were explored for some analogs of Brequinar having a linking atom between the 2-biphenyl substituent and the quinoline ring. Activities as inhibitors of dihydroorotate dehydrogenase and the mixed lymphocyte reaction were related to the overall shape and lipophilicity of the 2-substituent.

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