doi: 10.1016/s0960-894x(98)00440-5.
Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers
Affiliations
- PMID: 9873552
- DOI: 10.1016/s0960-894x(98)00440-5
Item in Clipboard
Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers
Bioorg Med Chem Lett.
.
Abstract
Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been identified. Their synthesis and preliminary pharmacology are discussed herein.
Similar articles
-
Synthesis and biological activity of substituted bis-(4-hydroxyphenyl)methanes as N-type calcium channel blockers.Bioorg Med Chem Lett. 1999 Aug 16;9(16):2447-52. doi: 10.1016/s0960-894x(99)00404-7. Bioorg Med Chem Lett. 1999. PMID: 10476885
-
Synthesis and biological evaluation of substituted 4-(OBz)phenylalanine derivatives as novel N-type calcium channel blockers.Bioorg Med Chem Lett. 1999 Apr 19;9(8):1121-6. doi: 10.1016/s0960-894x(99)00160-2. Bioorg Med Chem Lett. 1999. PMID: 10328297
-
5-Isoquinolinesulfonamide derivatives. 1. Synthesis and vasodilatory activity of N-(2-guanidinoethyl)-5-isoquinolinesulfonamide derivatives.J Med Chem. 1989 Jan;32(1):42-6. doi: 10.1021/jm00121a009. J Med Chem. 1989. PMID: 2909742
-
N,N-dialkyl-dipeptidylamines as novel N-type calcium channel blockers.Bioorg Med Chem Lett. 1999 Mar 22;9(6):907-12. doi: 10.1016/s0960-894x(99)00100-6. Bioorg Med Chem Lett. 1999. PMID: 10206559
-
Multiple parallel synthesis of N,N-dialkyldipeptidylamines as N-type calcium channel blockers.Bioorg Med Chem Lett. 1999 Jul 5;9(13):1813-8. doi: 10.1016/s0960-894x(99)00284-x. Bioorg Med Chem Lett. 1999. PMID: 10406647
Cited by
-
Development of small molecules that mimic the binding of omega-conotoxins at the N-type voltage-gated calcium channel.Mol Divers. 2004;8(2):127-34. doi: 10.1023/b:modi.0000025656.79632.86. Mol Divers. 2004. PMID: 15209164
-
Calcium channel blockers and pain therapy.Curr Rev Pain. 2000;4(6):488-98. doi: 10.1007/s11916-000-0073-8. Curr Rev Pain. 2000. PMID: 11060595 Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information
