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. 1998 Sep 22;8(18):2415-8.
doi: 10.1016/s0960-894x(98)00440-5.

Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers

P Yuen  1 , R M Schelkun, B Szoke, K Tarczy-Hornoch
Affiliations

Synthesis and structure-activity relationship of substituted 1,2,3,4-tetrahydroisoquinolines as N-type calcium channel blockers

P Yuen et al. Bioorg Med Chem Lett. .

Abstract

Voltage Activated Calcium Channel (VACC) blockers have been demonstrated to have utility in the treatment of pain and stroke. A series of aminomethyl substituted isoquinolinol derivatives with potent functional activity for N-type VACC's have been identified. Their synthesis and preliminary pharmacology are discussed herein.

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