doi: 10.1016/s0960-894x(98)00460-0.
New antifungals selected by molecular topology
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- PMID: 9873584
- DOI: 10.1016/s0960-894x(98)00460-0
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New antifungals selected by molecular topology
Bioorg Med Chem Lett.
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Abstract
Molecular topology has been applied to find the new lead antimycotic compounds. Among the selected compounds stands out 3,3'-(4,4'-Biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride), Benztropine mesylate and Dicyclopentamethylenethiuram disulphide, with minimum inhibitory concentrations between 1.6 and 2 micrograms/mL.
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