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. 1998 Sep 22;8(18):2577-82.
doi: 10.1016/s0960-894x(98)00460-0.

New antifungals selected by molecular topology

L Pastor  1 , R García-Domenech, J Gálvez, S Wolski, M D García
Affiliations

New antifungals selected by molecular topology

L Pastor et al. Bioorg Med Chem Lett. .

Abstract

Molecular topology has been applied to find the new lead antimycotic compounds. Among the selected compounds stands out 3,3'-(4,4'-Biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride), Benztropine mesylate and Dicyclopentamethylenethiuram disulphide, with minimum inhibitory concentrations between 1.6 and 2 micrograms/mL.

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