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. 1998 Oct 6;8(19):2737-42.
doi: 10.1016/s0960-894x(98)00497-1.

2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors

J Regan  1 , J Bruno, D McGarry, G Poli, B Hanney, S Bower, J Travis, D Sweeney, B Miller, J Souness, S Djuric
Affiliations

2-Substituted-4-methoxybenzimidazole-based PDE4 inhibitors

J Regan et al. Bioorg Med Chem Lett. .

Abstract

A new family of PDE4 inhibitors based on a benzimidazole framework is described. Several of these compounds are orally bioavailable and show efficacy in in vivo models of inflammatory disease.

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