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. 1998 Nov 3;8(21):3019-24.
doi: 10.1016/S0960-894X(98)00544-7.

Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid

P G Baraldi  1 , B Cacciari, A Guiotto, A Leoni, R Romagnoli, G Spalluto, N Mongelli, P W Howard, D E Thurston, N Bianchi, R Gambari
Affiliations

Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid

P G Baraldi et al. Bioorg Med Chem Lett. .

Abstract

We report the synthesis of a new hybrid 13 which is a combination of the naturally occurring antitumor agent distamycin A 1 and the pyrrolo[2,1-c][1,4]benzodiazepine 11, related to the naturally occurring anthramycin 2. The antitumor activity of the hybrid 13 was tested in vitro and compared to the natural product distamycin 1 and the PBD 11.

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