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. 1998 Nov 17;8(22):3203-6.
doi: 10.1016/s0960-894x(98)00554-x.

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D

C D Carroll  1 , T O Johnson, S Tao, G Lauri, M Orlowski, I Y Gluzman, D E Goldberg, R E Dolle
Affiliations

Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D

C D Carroll et al. Bioorg Med Chem Lett. .

Abstract

A structure-based 18,900-member combinatorial library was synthesized containing a statine template and three cyclic diamino acids as potential P1, P2-P4 surrogates. Evaluation of this encoded library against two aspartyl proteases, plasmepsin II and cathepsin D, led to the identification of selective inhibitors for each enzyme.

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