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. 1998 Dec 1;8(23):3335-40.
doi: 10.1016/s0960-894x(98)00589-7.

Potent inhibitors of the MAP kinase p38

J R Henry  1 , K C Rupert, J H Dodd, I J Turchi, S A Wadsworth, D E Cavender, P H Schafer, J J Siekierka
Affiliations

Potent inhibitors of the MAP kinase p38

J R Henry et al. Bioorg Med Chem Lett. .

Abstract

The MAP kinase p38 plays a key role in the biosynthesis of the inflammatory cytokines TNF-alpha and IL-1. We have developed a novel series of potent p38 inhibitors that could lead to new methods of treatment for inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.

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