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. 1998 Dec 1;8(23):3341-6.
doi: 10.1016/s0960-894x(98)00609-x.

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

G M Dubowchik  1 , R A Firestone
Affiliations

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

G M Dubowchik et al. Bioorg Med Chem Lett. .

Abstract

A series of lysosomal protease-sensitive peptides attached to doxorubicin (DOX) was prepared as model substrates for internalizing anticancer immunoconjugates and potential antimetastasis prodrugs. Rates of cathepsin B-mediated release of free drug was measured for each, and human plasma stabilities for representative examples.

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