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. 1998 Nov;176(5):442-7.
doi: 10.1016/s0002-9610(98)00238-4.

Tumor vascularity predicts recurrence in differentiated thyroid carcinoma

D K Dhar  1 , H Kubota, T Kotoh, H Tabara, R Watanabe, M Tachibana, H Kohno, N Nagasue
Affiliations

Tumor vascularity predicts recurrence in differentiated thyroid carcinoma

D K Dhar et al. Am J Surg. 1998 Nov.

Abstract

Background: New prognosticators are necessary for optimizing the extent of thyroidectomy and adjuvant radiotherapy in differentiated thyroid carcinoma.

Methods: Tumor microvessel density (MVD), expression of thymidine phosphorylase (dThdPase) and CD68 stained macrophages were evaluated in 71 differentiated thyroid carcinomas by an immunohistochemical method.

Results: The recurrence-free survival was significantly (P <0.05) shorter in patients with hypervascular tumors but was not related to the dThdPase expression. Significant (R = 0.323, P <0.001) correlation between dThdPase expression score and increment in MVD was documented. Frequent high MVD and dThdPase expression were encountered in tumors >3 cm. Twenty-two of the 27 (82%) patients expressing high dThdPase were also evaluated positive for CD68 (P <0.001).

Conclusions: Tumor MVD might be a new prognostic indicator of differentiated thyroid carcinoma, whereas dThdpase expression with high MVD might serve to identify a subgroup of thyroid carcinoma patients as potential candidates for adjuvant radiotherapy.

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