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Review
. 1999 Jan;88(1):14-27.
doi: 10.1021/js9801485.

Pharmacokinetic and metabolism studies using microdialysis sampling

D K Hansen  1 , M I Davies, S M Lunte, C E Lunte
Affiliations
Review

Pharmacokinetic and metabolism studies using microdialysis sampling

D K Hansen et al. J Pharm Sci. 1999 Jan.
No abstract available

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Figures

Figure 1
Figure 1
The microdialysis process.
Figure 2
Figure 2
General diagram of microdialysis system for sampling from an awake, freely moving animal. The analysis may be performed on a variety of analytical systems, and coupling between the analytical and microdialysis systems may be on- or off-line.
Figure 3
Figure 3
Microdialysis probe geometries (probes not drawn to scale). A. Intracerebral guide cannula and pin-style brain probe. B. Flexible probe for intravenous use. C. Linear probe for peripheral tissues. D. Shunt probe designed for sampling from bile duct of rat. (Used with permission of Bioanalytical Systems, Inc., West Lafayette, IN.)
Figure 4
Figure 4
Schematic of the on-line microdialysis/capillary electrophoresis system used for the analysis of SR4233.
Figure 5
Figure 5
Pharmacokinetic curve following a 4-mg/kg ip dose of SR4233 obtained using an on-line microdialysis/capillary electrophoresis system.
Figure 6
Figure 6
In vitro microdialysis sampling system for microsome or similar incubation process.
Figure 7
Figure 7
Metabolic profiles of diazapam metabolites sampled by microdialysis from liver microsome incubation mixture. Diazepam concentration was 145 M: (A) temazepam; (B) N-desmethyldiazepam; (C) oxazepam.
Figure 8
Figure 8
Placement of microdialysis probes implanted into the median lobe of the liver (viewed from the ventral surface) used to monitor phenol metabolism.
Figure 9
Figure 9
Typical concentration–time course for phenol (left) and hydroquinone (right) during and after a 20-min iv infusion of phenol (administration corresponding to 0–20 min).
Figure 10
Figure 10
Typical concentration–time course for phenyl-glucuronide (left) and glutathionyl-hydroquinone (right) during and after a 20-min iv infusion of phenol (administration corresponding to 0–20 min). Note: scale for the anterior probe is the right-hand axis.
See this image and copyright information in PMC

References

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