doi: 10.1073/pnas.96.1.5.
Why is Hu where? Shuttling of early-response-gene messenger RNA subsets
Affiliations
- PMID: 9874760
- PMCID: PMC33538
- DOI: 10.1073/pnas.96.1.5
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Why is Hu where? Shuttling of early-response-gene messenger RNA subsets
Proc Natl Acad Sci U S A.
.
No abstract available
Figures
Nuclear-cytoplasmic shuttling of the
ELAV/Hu protein HuR, which binds to a distinct subset of cellular
messenger RNAs. ERG mRNAs encoding protooncoproteins and cytokines are
bound to and stabilized by HuR, which contains an amino acid segment
(HNS) with both nuclear export and import elements (4). On reaching the
cytoplasm, HuR is assumed to release the ERG mRNAs for degradation or
translation and may then return to the nucleus (HuR-import) or degrade.
Nuclear pores through which mRNPs and proteins may pass are represented
as filled circles. The tension between these competing localization
signals results in a steady-state distribution of HuR between the
nucleus and cytoplasm and may determine the amounts of ERG mRNAs
available for translation. ERG mRNAs are assumed to be a subset of the
global heterogeneous mRNA population. The hnRNP proteins complexed with
ERG mRNAs may contain other nuclear-cytoplasmic shuttling
signals (41, 42).
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