Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1998 Sep;36(3):133-6.

Intradermal injection of tramadol has local anesthetic effect: a comparison with lidocaine

W W Pang  1 , M S Mok, D P Chang, T F Yang, C H Lin, M H Huang
Affiliations
  • PMID: 9874860
Clinical Trial

Intradermal injection of tramadol has local anesthetic effect: a comparison with lidocaine

W W Pang et al. Acta Anaesthesiol Sin. 1998 Sep.

Abstract

Background: We observed that intravenous retention of tramadol with a pneumatic tourniquet on the arm inflated to 70 mmHg for one minute could effectively reduce the subsequent propofol injection pain. Tramadol is a central-acting analgesic. The local analgesic effect of tramadol on reducing propofol injection pain is not well known.

Methods: To explore this problem we conducted a double-blind study on intradermal injections of tramadol 25 mg, lidocaine 5 mg and normal saline (all in 0.5 ml volume) which were given to each of the 10 healthy volunteers on the forearm at random. Pain on injections and the degree of local analgesia to pinprick, light touch and cold at each injection site were scored on a 0-4 scale at designated intervals.

Results: 5% tramadol, similar to 1% lidocaine, rendered loss of sensation to pin prick, light touch and cold for 30 min after intradermal injection as compared with normal saline (p < 0.01).

Conclusions: We concluded that intradermal injection of tramadol or lidocaine can produce local anesthetic effect.

PubMed Disclaimer