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. 1998 Feb;21(1):67-9.
doi: 10.1007/BF03216755.

Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii

S H Chae  1 , P S Kim, J Y Cho, J S Park, J H Lee, E S Yoo, K U Baik, J S Lee, M H Park
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Isolation and identification of inhibitory compounds on TNF-alpha production from Magnolia fargesii

S H Chae et al. Arch Pharm Res. 1998 Feb.

Abstract

Three TNF alpha-inhibitory lignans were isolated from the flower buds of Magnolia fargesii through bioassay-guided isolation. They were identified as eudesmin, magnolin and lirioresinol-B dimethylether on the basis of their spectroscopic data. All three lignans showed inhibitory effects on TNF-alpha production in LPS-stimulated murine macrophage cell line, RAW264.7 and eudesmin showed the strongest activity (IC50 = 51 microM).

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