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Comparative Study
. 1999 Jan;76(1 Pt 1):409-13.
doi: 10.1016/s0006-3495(99)77207-3.

Estimating the persistence length of a worm-like chain molecule from force-extension measurements

C Bouchiat  1 , M D Wang, J Allemand, T Strick, S M Block, V Croquette
Affiliations
Comparative Study

Estimating the persistence length of a worm-like chain molecule from force-extension measurements

C Bouchiat et al. Biophys J. 1999 Jan.

Abstract

We describe a simple computation of the worm-like chain model and obtain the corresponding force-versus-extension curve. We propose an improvement to the Marko and Siggia interpolation formula of Bustamante et al (Science 1994, 265:1599-1600) that is useful for fitting experimental data. We apply it to the experimental elasticity curve of single DNA molecules. Finally, we present a tool to study the agreement between the worm-like chain model and experiments.

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References

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