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. 1978 Jul;75(7):3479-83.
doi: 10.1073/pnas.75.7.3479.

Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone

G M Dunny, B L Brown, D B Clewell

Induced cell aggregation and mating in Streptococcus faecalis: evidence for a bacterial sex pheromone

G M Dunny et al. Proc Natl Acad Sci U S A. 1978 Jul.

Abstract

Recipient strains of Streptococcus faecalis produce a trypsin sensitive, heat resistant, nuclease resistant factor, designated clumping-inducing agent (CIA) which causes strains carrying certain conjugative plasmids to aggregate. RNA and protein synthesis but not DNA synthesis are required for aggregation to occur. Recipient filtrates that contain CIA activity also induce donors to mate at high frequencies. Introduction of a transferable plasmid into strains producing CIA dramatically reduces the amount of CIA activity produced by the strain but allows the strain to respond to exogenously added CIA. Our data suggest that CIA represents a bacterial sex hormone (pheromone).

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References

    1. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3721-5 - PubMed
    1. J Bacteriol. 1977 May;130(2):948-50 - PubMed
    1. Arch Oral Biol. 1964 May-Jun;9:291-8 - PubMed
    1. Annu Rev Biochem. 1977;46:641-68 - PubMed
    1. J Bacteriol. 1974 Jan;117(1):283-9 - PubMed

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