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Case Reports
. 1999 Jan;134(1):103-6.
doi: 10.1016/s0022-3476(99)70380-x.

A cluster of microvillous inclusion disease in the Navajo population

J F Pohl  1 , M D Shub, E E Trevelline, K Ingebo, G Silber, N Rayhorn, S Holve, D Hu
Affiliations
Case Reports

A cluster of microvillous inclusion disease in the Navajo population

J F Pohl et al. J Pediatr. 1999 Jan.

Abstract

We report 4 unrelated patients with characteristic microscopic findings of microvillous inclusion disease (MID) with early-onset phenotype. All 4 patients came from the Navajo reservation in northern Arizona. A literature search revealed a fifth unrelated Navajo child with MID. The unusually high incidence in this population indicates that a founder effect might be responsible for an increased frequency of this rare genetic disorder in the Navajo. It is recommended that all Navajo infants presenting with severe diarrhea during early infancy undergo investigation for MID.

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Comment in

  • Microvillous inclusion disease in Japan.
    Kaneko K, Shimizu T, Fujiwara S, Igarashi J, Ohtomo Y, Yamashiro Y. Kaneko K, et al. J Pediatr. 1999 Sep;135(3):400. doi: 10.1016/s0022-3476(99)70146-0. J Pediatr. 1999. PMID: 10484813 No abstract available.

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