Alterations in signal transducing molecule CD3 zeta in patients with neoplastic diseases
Affiliations
- PMID: 9883314
Item in Clipboard
Alterations in signal transducing molecule CD3 zeta in patients with neoplastic diseases
Arch Immunol Ther Exp (Warsz).
1998.
Abstract
The impairment of immune cell functions in cancer patients may result from impairment of signal transduction. Recent studies have demonstrated altered expression and function of signal transduction molecule CD3 zeta in T and natural killer cells in patients with neoplastic diseases. Tumor infiltrating lymphocytes are more affected than peripheral blood lymphocytes. CD3 zeta expression is more prominent in advanced stage of the disease and correlates with reduced proliferative response, IFN-gamma, IL-2, TNF-alpha production.
Similar articles
-
Decreased expression of signal-transducing zeta chain in peripheral T cells and natural killer cells in patients with cervical cancer.Clin Cancer Res. 1996 Nov;2(11):1825-8. Clin Cancer Res. 1996. PMID: 9816136
-
Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma.Clin Cancer Res. 1996 Jan;2(1):161-73. Clin Cancer Res. 1996. PMID: 9816103
-
Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity.Eur J Immunol. 1996 Jun;26(6):1308-13. doi: 10.1002/eji.1830260620. Eur J Immunol. 1996. PMID: 8647210
-
Alterations in the expression of signal-transducing CD3 zeta chain in T cells from patients with chronic inflammatory/autoimmune diseases.Arch Immunol Ther Exp (Warsz). 2007 Nov-Dec;55(6):373-86. doi: 10.1007/s00005-007-0042-6. Epub 2007 Dec 3. Arch Immunol Ther Exp (Warsz). 2007. PMID: 18060371 Review.
-
Chronic hepatitis C in the advanced adult and elderly subjects.Minerva Gastroenterol Dietol. 2009 Jun;55(2):145-57. Minerva Gastroenterol Dietol. 2009. PMID: 19305374 Review.
Cited by
-
The effect of peripheral blood lymphocyte stimulation on zeta chain expression and IL-2 production in Hodgkin's disease.Br J Cancer. 2001 May 18;84(10):1339-43. doi: 10.1054/bjoc.2001.1792. Br J Cancer. 2001. PMID: 11355944 Free PMC article.