[Cholinergic influence on the hemodynamics and excretory functions of the kidney]

Abstract

The review of publications on intrarenal targets of acetylcholine and on mechanisms of its effects on renal hemodynamics (renal blood flow, autoregulation and distribution of it, glomerular filtration rate, contractile structures of glomerulus) and excretory functions, (diuresis and electrolyte excretion). The literary data on an independence of tubular responses to acetylcholine from hemodynamic changes are adduced. Molecular mechanisms and a role of muscarinic receptors in acetylcholine action on kidney as well as a central cholinergic regulation of kidney function and effect of stimulation of efferent vagus on kidney are considered. The conclusion about a possibility of participation of the cholinergic system in control of renal blood flow and excretory function is down.