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Review
. 1998 Nov;10(10):685-92.
doi: 10.1016/s0898-6568(98)00035-7.

Diversity and complexity of ceramide signalling in apoptosis

T Okazaki  1 , T Kondo, T Kitano, M Tashima
Affiliations
Review

Diversity and complexity of ceramide signalling in apoptosis

T Okazaki et al. Cell Signal. 1998 Nov.

Abstract

Sphingolipid ceramide has emerged as a lipid messenger of cell functions including differentiation and apoptosis. Diverse kinds of stresses (ultraviolet, irradiation, heat shock and hypoxia) and biological factors (TNF-alpha, IFN-gamma and Fas antibody) require ceramide generation to execute apoptosis. The review summarises the diversity and complexity of up- and downstream of ceramide signalling in apoptosis and clinical implications of ceramide-induced apoptosis.

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