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. 1999 Jan;103(1):5-9.
doi: 10.1172/JCI5928.

Switched at birth: a new family for PECAM-1

P J Newman  1
Affiliations

Switched at birth: a new family for PECAM-1

P J Newman. J Clin Invest. 1999 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Schematic diagram of selected Ig-superfamily members bearing one or more ITIMs (adapted from ref. 48). See Table 2 for a complete list of Ig-ITIM family members that bind SHP-1, SHP-2, or both, as well as the detailed amino acid sequence separating the paired ITIMs. Ig, immunoglobulin; ILT, Ig-like transcript; ITIM, immunoreceptor tyrosine–based inhibitory motif; KIR, killer inhibitory receptor; PECAM-1, platelet endothelial cell adhesion molecule-1; PIR-B, paired Ig-like receptor-braking protein; SIRP, signal regulatory protein.
Figure 2
Figure 2
Organization of the genes encoding selected Ig-CAMs and Ig-ITIM family members. Note that Ig-ITIM family genes often contain a mini-exon encoding all or part of the signal peptide, and their cytoplasmic domains are encoded by multiple exons. Both of these features differ significantly from that of Ig-CAMs, in which the transmembrane and cytoplasmic domains, as well as the 3′-untranslated region, are often encoded by a single, fused exon. ICAM-1, intercellular cell adhesion molecule-1; Ig-CAMs, Ig-like cell adhesion molecules; VCAM-1, vascular cell adhesion molecule-1.
See this image and copyright information in PMC

References

    1. Newman PJ. The biology of PECAM-1. J Clin Invest. 1997;99:3–8. - PMC - PubMed
    1. Newman PJ, et al. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. 1990;247:1219–1222. - PubMed
    1. Vivier E, Daeron M. Immunoreceptor tyrosine-based inhibition motifs. Immunol Today. 1997;18:286–291. - PubMed
    1. Cambier JC. Inhibitory receptors abound? [comment] Proc Natl Acad Sci USA. 1997;94:5993–5995. - PMC - PubMed
    1. Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE. Crystal structure of the tyrosine phosphatase SHP-2. Cell. 1998;92:441–450. - PubMed

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