Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Jan 19;96(2):324-6.
doi: 10.1073/pnas.96.2.324.

Development of optimized vectors for gene therapy

G J Nabel  1
Affiliations

Development of optimized vectors for gene therapy

G J Nabel. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Features of an optimized adenovirus gene therapy vector. Schematic diagram of a gutted adenoviral vector with an adenoviral packaging sequence and terminal repeats (ITR), containing a minimum of adenoviral genome sequences. The indicated regulatory sequences are intended to confer tissue-specific, regulatable gene expression and the inability to synthesize natural viral gene products.
Figure 2
Figure 2
Model of selective and inducible gene expression with ligand-regulated adenoviral vector. Gray area (Left) shows initial distribution of vector after intravenous injection. In the absence of drug treatment, vector gene expression remains minimal (Center). It is markedly increased, primarily in the liver, in a reversible fashion after drug administration (Right).
See this image and copyright information in PMC

Comment on

References

    1. Verma I M, Somia N. Nature (London) 1997;389:239–242. - PubMed
    1. Burcin M M, Schiedner G, Kochanek S, Tsai S Y, O’Malley B W. Proc Natl Acad Sci USA. 1999;96:355–360. - PMC - PubMed
    1. Clemens P R, Kochanek S, Sunada Y, Chan S, Chen H H, Campbell K P, Caskey C T. Gene Ther. 1996;3:965–972. - PubMed
    1. Haecker S E, Stedman H H, Balice-Gordon R J, Smith D B, Greelish J P, Mitchell M A, Wells A, Sweeney H L, Wilson J M. Hum Gene Ther. 1996;7:1907–1914. - PubMed
    1. Kochanek S, Clemens P R, Mitani K, Chen H H, Chan S, Caskey C T. Proc Natl Acad Sci USA. 1996;93:5731–5736. - PMC - PubMed

MeSH terms