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. 1976;26(6):1094-6.

[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Neurochemical findings (author's transl)]

[Article in German]
H R Bürki, A C Sayers, W Ruch, H Asper
  • PMID: 989385

[Effects of anticholinergics and clozapine on the activation of the striatal dopaminergic system in the rat by haloperidol. Neurochemical findings (author's transl)]

[Article in German]
H R Bürki et al. Arzneimittelforschung. 1976.

Abstract

The increase in the concentration of homovanillic acid (HVA) in the haloperidol for 6 days compared to a single administration of the drug. The induction of tolerance is probably due to a functional modification of the striatal dopamine (DA)-receptors after repeated administration of the neuroleptic. Atropine given in combination with haloperidol enhances the induction of tolerance. Clozapine (20 mg/kg orally) had no such effect.

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