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. 1976;26(6):1149-51.

[On improved prophylaxis of endogenous-phasic psychoses: aspects of parallel determination of lithium in serum and erythrocytes (author's transl)]

[Article in German]
L Demisch, H J Bochnik
  • PMID: 989403

[On improved prophylaxis of endogenous-phasic psychoses: aspects of parallel determination of lithium in serum and erythrocytes (author's transl)]

[Article in German]
L Demisch et al. Arzneimittelforschung. 1976.

Abstract

In 30% of the psychiatric patients investigated the lithium concentration in erythrocytes (RBC-lithium) is a more reliable indicator for the evaluation of the clinical response and the risk of toxicity. After lithium administration the lithium RBC levels increased within the first three weeks. Lithium RBC/plasma ratios are not different between unipolar, bipolar and schizo-affective psychoses. It was found that low lithium RBC/plasma ratios correspond with low monoamine oxidase (MAO) activity in platelets.

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