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Review
. 1998 Dec;10(6):791-7.
doi: 10.1016/s0955-0674(98)80123-3.

Negative control elements of the cell cycle in human tumors

P D Adams  1 , W G Kaelin Jr
Affiliations
Review

Negative control elements of the cell cycle in human tumors

P D Adams et al. Curr Opin Cell Biol. 1998 Dec.

Abstract

The retinoblastoma protein and p53 are both cell-cycle regulators and are, directly or indirectly, inactivated in the majority of human tumors. Recent studies have provided new mechanistic insights into how these proteins regulate cell growth in response to various intracellular and extracellular signals.

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