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Comparative Study
. 1999 Jan;80(1):54-8.
doi: 10.1016/s0003-9993(99)90307-6.

Muscle strength in the elderly: its relation to vitamin D metabolites

H A Bischoff  1 , H B Stahelin, N Urscheler, R Ehrsam, R Vonthein, P Perrig-Chiello, A Tyndall, R Theiler
Affiliations
Comparative Study

Muscle strength in the elderly: its relation to vitamin D metabolites

H A Bischoff et al. Arch Phys Med Rehabil. 1999 Jan.

Abstract

Objective: To identify a relation between loss of muscle strength and vitamin D deficiency in ambulatory elderly persons not receiving vitamin D supplementation.

Design: Cross-sectional study.

Setting: All measurements were taken at the Department of Geriatrics, University Hospital, Basel, Switzerland.

Subjects: Three hundred nineteen patients (103 women, 216 men) selected by random sampling from participants in an ongoing interdisciplinary study on aging (mean age for women, 74.2 yrs; for men, 76.7 yrs).

Outcome measures: Leg extension power (LEP) and body mass index (BMI); serum values of 25-hydroxyvitamin D [calcidiol, 25(OH)D], 1,25-hydroxyvitamin D [calcitriol, 1,25(OH)2D], and intact parathyroid hormone (iPHT).

Results: Twelve percent of women and 18% of men had 25(OH)D values below the normal range (<12 ng/mL). Muscle strength was lower in older subjects (female: r = -.35; p = .0005/male: r = -.48; p < .0001) and was lower in women than in men (p < .0001). In men both 25(OH)D and 1,25(OH)2D was significantly correlated with LEP (r = 0.24; p = .0004/r = .14; p = .045). In women, only 1,25(OH)2D was significantly correlated with LEP (r = 0.22; p = .034). In an ANCOVA including all participants and explaining LEP by sex, age, BMI, 1,25(OH)2D, 25(OH)D, and iPTH, all factors showed significant effects except 25(OH)D and iPTH (r2 = .41).

Conclusion: Muscle strength declined with age in ambulatory elderly people and showed modest, but significant, positive correlation with 1,25(OH)2 vitamin D in both sexes and with 25(OH)D in male subjects. Therefore vitamin D deficiency appears to contribute to the age-related loss of muscle strength, which might be more pronounced in institutionalized elderly people with a high prevalence of vitamin D deficiency.

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Comment in

  • Muscle strength and vitamin D.
    Falkenbach A. Falkenbach A. Arch Phys Med Rehabil. 2000 Feb;81(2):241. doi: 10.1016/s0003-9993(00)90149-7. Arch Phys Med Rehabil. 2000. PMID: 10668783 No abstract available.

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