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Comment
. 1999 Jan;103(2):157-8.
doi: 10.1172/JCI6127.

Blood vessel maturation: vascular development comes of age

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Comment

Blood vessel maturation: vascular development comes of age

D C Darland et al. J Clin Invest. 1999 Jan.
No abstract available

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Figures

Figure 1
Figure 1
Vessel maturation: vessel development proceeds from a stage of growth-factor dependence where loss of a survival factor leads to apoptosis. Vessel stabilization is marked by investment with mural cells, local activation of TGF-β, and basement membrane production. The angiopoietins are clearly implicated, though their precise roles are yet to be determined.

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References

    1. Clark ER, Clark EL. Microscopic observations on the growth of blood capillaries in the living mammal. Am J Anat. 1939;64:251–299.
    1. Ausprunk DH, Knighton DR, Folkman J. Differentiation of vascular endothelium in the chick chorioallantois: a structural and autoradiographic study. Devel Biol. 1974;38:237–248. - PubMed
    1. Benjamin LE, Golijanin D, Itin A, Pode D, Keshet E. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest. 1999;103:159–165. - PMC - PubMed
    1. Crocker DJ, Murad TM, Greer JC. Role of the pericyte in wound healing. An ultrastructural study. Exp Mol Pathol. 1970;13:51–65. - PubMed
    1. Speiser P, Gitttelsohn AM, Patz A. Studies on diabetic retinopathy. III. Influence of diabetes on intramural pericytes. Arch Ophthalmol. 1968;80:332–337. - PubMed

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