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. 1999 Jan;62(1):94-7.
doi: 10.1021/np980291d.

Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba

D F Chen  1 , S X Zhang, H K Wang, S Y Zhang, Q Z Sun, L M Cosentino, K H Lee
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Novel anti-HIV lancilactone C and related triterpenes from Kadsura lancilimba

D F Chen et al. J Nat Prod. 1999 Jan.

Abstract

Three new triterpene lactones, lancilactones A (1), B (2), and C (3), together with the known kadsulactone A (4), were isolated from the stems and roots of Kadsura lancilimba. Their structures and stereochemistries were determined primarily from mass and NMR spectral data. Compound 3 inhibited HIV replication with an EC50 value of 1.4 microg/mL and a therapeutic index of greater than 71.4.

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