The origin of experimental brain tumours: a sequential study
- PMID: 992001
- DOI: 10.1007/BF01937439
The origin of experimental brain tumours: a sequential study
Abstract
A sequential study of rat brains treated transplacetally with the neurotropic carcinogen ethylnitrosourea reveals small foci of cell proliferations from the age of 8 weeks. These lesions consist mainly of undifferentiated cells of the subependymal plate type. They occur in those areas in which gliomas develop and represent the earliest, histologically detectable, changes in the development of brain tumours.
Similar articles
-
The development of experimental brain tumours. A sequential light and electron microscope study of the subependymal plate. I. Early lesions (abnormal cell clusters).Acta Neuropathol. 1979 Mar 15;45(3):167-75. doi: 10.1007/BF00702668. Acta Neuropathol. 1979. PMID: 442982
-
The role of the subependymal plate in the origin of gliomas induced by ethylnitrosourea in the rat brain.Experientia. 1977 Apr 15;33(4):521-2. doi: 10.1007/BF01922250. Experientia. 1977. PMID: 862760
-
[Experimental brain neoplasm induced transplacentally by ethylnitrosourea (ENU). (1) Sequential, localized observations and pathological studies of microtumors].No To Shinkei. 1976 Dec;28(12):1319-26. No To Shinkei. 1976. PMID: 1036033 Japanese. No abstract available.
-
Development of nitrosourea-induced brain tumours--with a special note on changes occurring during latency.Food Chem Toxicol. 1986 Feb;24(2):121-7. doi: 10.1016/0278-6915(86)90346-7. Food Chem Toxicol. 1986. PMID: 3514397 Review.
-
In-vivo-in-vitro analysis of ethylnitrosourea-induced brain carcinogenesis in the rat.Br Med Bull. 1980 Jan;36(1):33-8. doi: 10.1093/oxfordjournals.bmb.a071610. Br Med Bull. 1980. PMID: 7020827 Review. No abstract available.
Cited by
-
Glioma Stem Cells: Signaling, Microenvironment, and Therapy.Stem Cells Int. 2016;2016:7849890. doi: 10.1155/2016/7849890. Epub 2016 Jan 6. Stem Cells Int. 2016. PMID: 26880988 Free PMC article. Review.
-
A Prospective Cohort Study of Neural Progenitor Cell-Sparing Radiation Therapy Plus Temozolomide for Newly Diagnosed Patients With Glioblastoma.Neurosurgery. 2020 Jul 1;87(1):E31-E40. doi: 10.1093/neuros/nyaa107. Neurosurgery. 2020. PMID: 32497183 Free PMC article.
-
The development of experimental brain tumours. A sequential light and electron microscope study of the subependymal plate. I. Early lesions (abnormal cell clusters).Acta Neuropathol. 1979 Mar 15;45(3):167-75. doi: 10.1007/BF00702668. Acta Neuropathol. 1979. PMID: 442982
-
Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors.Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10361-6. doi: 10.1073/pnas.96.18.10361. Proc Natl Acad Sci U S A. 1999. PMID: 10468613 Free PMC article.
-
Effect of dietary vitamin A or N-acetylcysteine on ethylnitrosourea-induced rat gliomas.J Neurooncol. 1998 Oct;40(1):29-38. doi: 10.1023/a:1006171730876. J Neurooncol. 1998. PMID: 9874183