[Effect of thyroxine and 2,4-dinitrophenol on cardiac energetics]
[Article in
Russian]
- PMID: 992140
Item in Clipboard
[Effect of thyroxine and 2,4-dinitrophenol on cardiac energetics]
[Article in
Russian]
Fiziol Zh SSSR Im I M Sechenova.
1976 Aug.
Abstract
The administrations of 1-thyrohine (20 mg/kg) for two sucessive daysin the rats or 10(-3) M 2,4-dinitrophenol (2,4-DNP) in vitro reduced the mechanical of the heart in working isolated preparations of the rat heart. Oxygen consumption of inactive heart did not react to thyroxine and significantly increased after 2,4-DNP administration. The reduction of the heart efficiency due to thyroxine is, probably, associated with a decreased efficiency of mechanochemical conjugation in the myocardium muscular fibers.
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