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Case Reports
. 1999 Jan;40(1):91-4.
doi: 10.1016/s0190-9622(99)70533-5.

Effect of colchicine in the subcorneal pustular dermatosis type of IgA pemphigus

E Hodak  1 , M Lapidoth, M David
Affiliations
Case Reports

Effect of colchicine in the subcorneal pustular dermatosis type of IgA pemphigus

E Hodak et al. J Am Acad Dermatol. 1999 Jan.

Abstract

Background: IgA pemphigus of the subcorneal pustular dermatosis (SPD) type is characterized by subcorneal acantholysis and by an abundance of neutrophils, making colchicine a reasonable pharmacologic option for treatment.

Objective: We attempted to determine the efficacy of colchicine in the treatment of SPD-type IgA pemphigus.

Methods: Two patients with SPD-type IgA pemphigus were treated with colchicine 1.5 mg/day as monotherapy.

Results: A sustained clinical response was achieved within 2 to 3 weeks of therapy. Relapses were noted each time colchicine was stopped.

Conclusion: Colchicine should be considered in the treatment of SPD-type IgA pemphigus.

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