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. 1976 Dec;357(10):1147-20.

[Redioimmunoassay for secretin (author's transl)]

[Article in German]
E Wünsch, E Jaeger, L Moroder, L Demling, W Domschke, M Reiss
  • PMID: 992560

[Redioimmunoassay for secretin (author's transl)]

[Article in German]
E Wünsch et al. Hoppe Seylers Z Physiol Chem. 1976 Dec.

Abstract

The synthesis of a secretin with an elongated N-terminus, namely Nalpha-(deaminotyrosyl-beta-alanyl)- secretin (DATA-secretin), using a conventional strategy, is described. After purification of the product by means of ion exchange chromatography on SP-Sephadex C-25 and by continuous carrier-free electrophoresis, immunological studies on the synthetic DATA-secretin were carried out using secretin antibodies. In comparison to 125iodine-labelled secretin and [Tyr6]secretin, 125iodine-DATA-secretin proved to be by far the best "tracer". Elaboration of a radioimmunoassay for secretin is therefore possible.

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