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Comment
. 1999 Feb 1;189(3):447-50.
doi: 10.1084/jem.189.3.447.

Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs

J G Cyster  1
Affiliations
Comment

Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs

J G Cyster. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
Homing of LCs to LN T zones. Multiple types of stimuli cause epidermal LCs to downregulate receptors for chemokines produced locally at the site of inflammation and to upregulate CCR7. One CCR7 ligand, SLC, is made by LN HEVs and stromal cells, and by lymphatic endothelial cells (reference ; although dermal lymphatics have not yet been tested for SLC expression). A second ligand, ELC, is made by T zone DCs and possibly other T zone stromal cells (reference 19). These CCR7 ligands help direct migration of LCs to the LN T zone where they function as immunogenic APCs. Dark shading shows an LC moving from the epidermis to become a veiled cell in the lymph and subsequently an interdigitating DC in the T zone. Light shading shows B cell areas, where B lymphocyte chemoattractant (BLC) is made (reference 34). Not shown are the many other cell types, including monocyte-derived DCs, that travel via afferent lymphatics to the LN T zone. Within the T zone, chemokines (including SLC, ELC, BLC, and SDF), extracellular matrix components, and adhesion molecules all may influence the final positioning and cell–cell interactions of the different DCs.
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Comment on

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