COX-2 inhibitors
- PMID: 9929039
- DOI: 10.1016/s0140-6736(98)12154-2
COX-2 inhibitors
Abstract
In the past 100 years aspirin has demonstrated its value as an analgesic, anti-inflammatory, and antithrombotic agent. However, by 1938, it was clear that aspirin was gastrotoxic. Non-steroidal anti-inflammatory drugs (NSAIDs), developed since the 1960s, failed to achieve the goal of "a safer aspirin". The demonstration that inhibition of prostaglandin synthesis via a cyclo-oxygenase (COX) enzyme was central to both the therapeutic and toxic effects of aspirin and non-aspirin NSAIDs appeared to establish the principle of no gain without pain. This link may have been broken by drugs that selectively inhibit the inducible COX-2 enzyme. The COX enzyme is now a target of drug interventions against the inflammatory process. Might the "safe aspirin" be here at last?
Comment in
-
COX-2 inhibitors.Lancet. 1999 Apr 24;353(9162):1439; author reply 1440. doi: 10.1016/S0140-6736(99)00074-4. Lancet. 1999. PMID: 10227242 No abstract available.
-
COX-2 inhibitors.Lancet. 1999 Apr 24;353(9162):1439-40. doi: 10.1016/s0140-6736(05)75960-2. Lancet. 1999. PMID: 10227243 No abstract available.
-
COX-2 inhibitors.Lancet. 1999 Apr 24;353(9162):1440. doi: 10.1016/S0140-6736(05)75961-4. Lancet. 1999. PMID: 10227244 No abstract available.
Similar articles
-
COX-2-Specific inhibitors--the emergence of a new class of analgesic and anti-inflammatory drugs.Clin Rheumatol. 2000;19(5):331-43. doi: 10.1007/s100670070024. Clin Rheumatol. 2000. PMID: 11055820 Review.
-
A new class of COX-2 inhibitors offer an alternative to NSAIDS in pain management after spinal surgery.Spine (Phila Pa 1976). 2001 Jul 1;26(13):1505-6. doi: 10.1097/00007632-200107010-00028. Spine (Phila Pa 1976). 2001. PMID: 11458162 No abstract available.
-
The new NSAIDs: cox-2 inhibitors.Medsurg Nurs. 2000 Dec;9(6):313-7. Medsurg Nurs. 2000. PMID: 11904867 Review. No abstract available.
-
Tolerability of three selective cyclo-oxygenase-2 inhibitors, meloxicam, celecoxib and rofecoxib in NSAID-sensitive patients.Eur Ann Allergy Clin Immunol. 2004 Jun;36(6):215-8. Eur Ann Allergy Clin Immunol. 2004. PMID: 15329003 Clinical Trial.
-
The new COX-2 inhibitors: rofecoxib (Vioxx) and celecoxib (Celebrex).Gen Dent. 2000 Jan-Feb;48(1):16-20. Gen Dent. 2000. PMID: 11199547 No abstract available.
Cited by
-
Study of osteoarthritis treatment with anti-inflammatory drugs: cyclooxygenase-2 inhibitor and steroids.Biomed Res Int. 2015;2015:595273. doi: 10.1155/2015/595273. Epub 2015 Apr 27. Biomed Res Int. 2015. PMID: 26000299 Free PMC article.
-
Extraintestinal Complications of Inflammatory Bowel Disease.Curr Treat Options Gastroenterol. 2001 Jun;4(3):227-243. doi: 10.1007/s11938-001-0035-1. Curr Treat Options Gastroenterol. 2001. PMID: 11469980
-
Comparison of reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis in association with selective COX-2 inhibitors.Drug Saf. 2005;28(10):917-24. doi: 10.2165/00002018-200528100-00008. Drug Saf. 2005. PMID: 16180941
-
Pathogenesis of aspirin-exacerbated respiratory disease.Clin Rev Allergy Immunol. 2003 Apr;24(2):169-88. doi: 10.1385/CRIAI:24:2:169. Clin Rev Allergy Immunol. 2003. PMID: 12668897 Review.
-
Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes.Rheumatol Int. 2008 Jun;28(8):727-36. doi: 10.1007/s00296-007-0511-6. Epub 2007 Dec 14. Rheumatol Int. 2008. PMID: 18080123
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous
