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. 1976 Nov;58(5):1119-22.
doi: 10.1172/JCI108564.

Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma

J B Smith, C Ingerman, M J Silver

Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma

J B Smith et al. J Clin Invest. 1976 Nov.

Abstract

During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the time-course of its appearance and disappearance, this release-inducing activity could be dissociated from prostaglandin endoperoxides and associated with thromboxane A2-like material. This material persists in plasma because of its continued production and increased stability.

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