Review
doi: 10.1007/3-540-69791-8_8.
Microbial models for drug metabolism
Affiliations
- PMID: 9933985
- DOI: 10.1007/3-540-69791-8_8
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Review
Microbial models for drug metabolism
Adv Biochem Eng Biotechnol.
1999.
Abstract
This review describes microbial transformation studies of drugs, comparing them with the corresponding metabolism in animal systems, and providing technical methods for developing microbial models. Emphasis is laid on the potential for selected microorganisms to mimic all patterns of mammalian biotransformations and to provide preparative methods for structural identification and toxicological and pharmacological studies of drug metabolites.
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