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. 1998 Dec 15;8(24):3637-42.
doi: 10.1016/s0960-894x(98)00670-2.

Design and synthesis of novel conformationally restricted HIV protease inhibitors

F G Salituro  1 , C T Baker, J J Court, D D Deininger, E E Kim, B Li, P M Novak, B G Rao, S Pazhanisamy, M D Porter, W C Schairer, R D Tung
Affiliations

Design and synthesis of novel conformationally restricted HIV protease inhibitors

F G Salituro et al. Bioorg Med Chem Lett. .

Abstract

A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.

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