[Measurements of intraocular gentamicin concentration using hydrophilic contact lenses as drug delivery system (author's transl)]

Abstract

Investigations were performed with two groups of anaesthetised rabbits to test the possibility of increasing the penetration of topically administered. Gentamicin into the eye through the use of hydrophilic contact lenses. After application of Gentamicin drops the drug concentration in the aqueous humour was biologically quantitated. In the first group one eye of the animal was fitted with a hydrophilic contact lens and the other eye was submitted to a comparative measurement. In the second group both eyes were fitted with contact lenses which had been soaked in Gentamicin solutions of two different con-entrations. The result showed an increased intraocular Gentamicin level in the eyes fitted with hydrophilic contact lenses. However, in the latter group we found low intraocular drug levels where only contact lenses soaked in Gentamicin solution were used.