Studies on the transfer of protective immunity with lymphoid cells from mice immune to malaria sporozoites
- PMID: 99475
Studies on the transfer of protective immunity with lymphoid cells from mice immune to malaria sporozoites
Abstract
In an effort to understand the mechanisms involved in the protective immunity to malarial sporozoites, an A/J mouse/Plasmodium berghei model was studied. Protective immunity could consistently be adoptively transferred only by using sublethal irradiation of recipients (500 R); a spleen equivalent (100 X 10(6))of donor cells from immune syngeneic mice; and a small booster immunization (1 X 10(4)) of recipients with irradiation-attenuated sporozoites. Recipient animals treated in this manner were protected from lethal challenge with 1 X 10(4) nonattenuated sporozoites. Immune and nonimmune serum and spleen cells from nonimmune animals did not protect recipient mice. Fewer immune spleen cells (50 X 10(6)) protected some recipients. In vitro treatment of immune spleen cells with anti-theta sera and complement abolished their ability to transfer protection. This preliminary study suggests that protective sporozoite immunity can be transferred with cells, and that it is T cell dependent.
Similar articles
-
Use of adoptive transfer and Winn assay procedures in the further analysis of antiviral acquired immunity in mice protected against Friend leukemia virus-induced disease by passive serum therapy.Cancer Res. 1984 Apr;44(4):1489-98. Cancer Res. 1984. PMID: 6608407
-
Immune mechanisms in leukemia: protective capacity of the major lymphoid cell compartments.J Immunol. 1976 Apr;116(4):976-81. J Immunol. 1976. PMID: 1082909
-
MHC-unrestricted transfer of antilisterial immunity by freshly isolated immune CD8 spleen cells.J Immunol. 1989 Dec 1;143(11):3731-6. J Immunol. 1989. PMID: 2479688
-
Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. Relevance to vaccine development.J Immunol. 1989 Sep 15;143(6):2017-23. J Immunol. 1989. PMID: 2570802
-
Targeting to lymphoid cells of the immune network.Pharmacol Ther. 1983;21(3):295-323. doi: 10.1016/0163-7258(83)90058-x. Pharmacol Ther. 1983. PMID: 6195681 Review. No abstract available.
Cited by
-
Evaluation of vaccines designed to induce protective cellular immunity against the Plasmodium yoelii circumsporozoite protein: vaccinia, pseudorabies, and Salmonella transformed with circumsporozoite gene.Bull World Health Organ. 1990;68 Suppl(Suppl):109-14. Bull World Health Organ. 1990. PMID: 2094576 Free PMC article.
-
Anti-sporozoite antibodies.Bull World Health Organ. 1990;68 Suppl(Suppl):47-51. Bull World Health Organ. 1990. PMID: 2094591 Free PMC article. Review.
-
Human T-cell recognition of the circumsporozoite protein of Plasmodium falciparum: immunodominant T-cell domains map to the polymorphic regions of the molecule.Proc Natl Acad Sci U S A. 1988 Feb;85(4):1199-203. doi: 10.1073/pnas.85.4.1199. Proc Natl Acad Sci U S A. 1988. PMID: 2448793 Free PMC article.
-
Use of a tuberculin purified protein derivative--Asn-Ala-Asn-Pro conjugate in bacillus Calmette-Guérin primed mice overcomes H-2 restriction of the antibody response and avoids the need for adjuvants.Proc Natl Acad Sci U S A. 1990 Apr;87(8):2960-4. doi: 10.1073/pnas.87.8.2960. Proc Natl Acad Sci U S A. 1990. PMID: 2183219 Free PMC article.
-
CD8+ T cells (cytotoxic/suppressors) are required for protection in mice immunized with malaria sporozoites.Proc Natl Acad Sci U S A. 1988 Jan;85(2):573-6. doi: 10.1073/pnas.85.2.573. Proc Natl Acad Sci U S A. 1988. PMID: 2963334 Free PMC article.