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Review
. 1998 Dec;15(4):222-8.
doi: 10.1007/BF02787204.

New p53-based anti-cancer therapeutic strategies

K G Wiman  1
Affiliations
Review

New p53-based anti-cancer therapeutic strategies

K G Wiman. Med Oncol. 1998 Dec.

Abstract

The p53 gene is frequently mutated in human tumours and therefore an important target for therapeutic intervention. Several p53-based strategies for treatment of cancer are currently under development. p53 gene therapy has resulted in tumour regression in patients with lung cancer. A mutant adenovirus can obliterate tumour cells carrying mutant p53 or lacking p53, but is unable to replicate in normal cells. Furthermore, current studies suggest that reactivation of mutant p53 proteins in tumours using small p53-activating molecules may initiate p53-dependent apoptosis and thus eliminate the tumour.

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References

    1. Genes Dev. 1993 Apr;7(4):546-54 - PubMed
    1. J Biol Chem. 1995 Mar 10;270(10):5405-11 - PubMed
    1. Nat Med. 1997 Jun;3(6):606-8 - PubMed
    1. Nature. 1997 Feb 13;385(6617):637-40 - PubMed
    1. Nat Med. 1997 Mar;3(3):313-9 - PubMed

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