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Clinical Trial
. 1975 Dec;2(6):509-13.
doi: 10.1111/j.1365-2125.1975.tb00568.x.

Inhibition of gastric emptying and drug absorption by narcotic analgesics

W S Nimmo, R C Heading, J Wilson, P Tothill, L F Prescott
Clinical Trial

Inhibition of gastric emptying and drug absorption by narcotic analgesics

W S Nimmo et al. Br J Clin Pharmacol. 1975 Dec.

Abstract

The effect of intramuscular pethidine or diamorphine on gastric emptying and the absorption of orally administered paracetamol was assessed in eight normal subjects. 2 Both drugs produced a significant and striking delay in gastric emptying and absorption of paracetamol. 3 It seems inevitable that pethidine and diamorphine will retard the absorption of other orally administered drugs.

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