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. 1976 Oct;3(10):2861-75.
doi: 10.1093/nar/3.10.2861.

Induction of interferon by polyribonucleotides containing thiopyrimidines

K Reuss, K H Scheit, O Saiko
Free PMC article

Induction of interferon by polyribonucleotides containing thiopyrimidines

K Reuss et al. Nucleic Acids Res. 1976 Oct.
Free PMC article

Abstract

The influence of thioketo substitution in pyrimidine bases of double-stranded polynucleotides on interferon induction was investigated. The stabilizing effect of 2-thioketo substitution was reflected in the increased interferon inducing activity of poly(A-s2U) over that of poly(A-U). Poly(A-s2U) and poly(I)-poly(s2C) were as effective as poly(I)-Poly(C) in rabbit cells. Poly(I)-poly(C) and poly(I)-poly(s2C) were compared in several animal species. No differences in biological effects were observed in rabbits and dogs. In rodents, poly(I)-poly(s2C) was less effective and less toxic.Poly(I)-poly(s2C) was highly resistant against degradation by human serum. Further investigations seem to be justified to elucidate whether this property offers any advantages for the potential clinical utilization of poly(I)-poly(s2C).

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