Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Dec 10;194(4270):1173-4.
doi: 10.1126/science.996548.

Is there selection against wobble in codon-anticodon pairing?

W M Fitch

Is there selection against wobble in codon-anticodon pairing?

W M Fitch. Science. .

Abstract

Among amino acid codons that require a third-position pyrimidine, there is a significant bias favoring the use of cytidine over uracil in MS2 phage RNA. This could arise from selection against wobble pairing in the interaction of transfer RNA and messenger RNA. Among amino acid codons with fourfold degeneracy, there is a bias favoring pyrimidines over purines.

PubMed Disclaimer

Publication types

LinkOut - more resources