doi: 10.1007/BF00501380.
Increase of liver microsomal benzo(a)pyrene monooxygenase activity by subsequent glucuronidation
- PMID: 99672
- DOI: 10.1007/BF00501380
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Increase of liver microsomal benzo(a)pyrene monooxygenase activity by subsequent glucuronidation
Naunyn Schmiedebergs Arch Pharmacol.
1978 Aug.
Abstract
Benzo(a)pyrene monooxygenase activity in rat and guinea pig liver microsomes is markedly stimulated when UDP-glucuronic acid is present in the assay. This effect is further enhanced by addition of UDP-N-acetylglucosamine, an allosteric activator of UDP-glucuronyltransferase. The results suggest a coupling between microsomal monooxygenase and UDP-glucuronyltransferase which may assist elimination of toxic compounds.
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