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. 1976 Jul;6(7):405-9.
doi: 10.3109/00498257609151653.

Metabolism of debrisoquine sulphate in rat, dog and man

J G Allen, A N Brown, T R Marten

Metabolism of debrisoquine sulphate in rat, dog and man

J G Allen et al. Xenobiotica. 1976 Jul.

Abstract

1. The metabolism of debrisoquine sulphate in the dog has been studied and is similar to that in rat and man. 2. Two acidic urinary metabolites, shown to be present in rat, dog and man, have been isolated from rat urine. After derivatization they were characterized by n.m.r. and mass spectroscopy as methyl 2-[2-(4,6-dimethylpyrimidylamino)-methyl]-phenylacetate and 2-[2-(4,6-dimethylpyrimidylamino)-ethyl]benzoate.

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