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. 1999 Jan 25;443(2):105-8.
doi: 10.1016/s0014-5793(98)01694-9.

The intramitochondrial ATP/ADP-ratio controls cytochrome c oxidase activity allosterically

S Arnold  1 , B Kadenbach
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Free article

The intramitochondrial ATP/ADP-ratio controls cytochrome c oxidase activity allosterically

S Arnold et al. FEBS Lett. .
Free article

Abstract

Recently the signal transduction function for oxidative phosphorylation was found to be second order in ADP [Jeneson, J.A.L., Wiseman, R.W., Westerhoff, H.V. and Kushmerick, M.J. (1996) J. Biol. Chem. 271, 27995-279981, but the molecular mechanism of signal transduction remained unclear. Previously we described inhibition of cytochrome c oxidase by intramitochondrial ATP, accompanied by a change of hyperbolic into sigmoidal kinetics. The present study describes a sigmoidal relationship also between the ascorbate respiration of reconstituted cytochrome c oxidase and intraliposomal ADP concentration. Its possible role in the control of oxidative phosphorylation and cell respiration is discussed.

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