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Review
. 1999 Feb 15;189(4):611-4.
doi: 10.1084/jem.189.4.611.

Mobilizing dendritic cells for tolerance, priming, and chronic inflammation

F Sallusto  1 , A Lanzavecchia
Affiliations
Review

Mobilizing dendritic cells for tolerance, priming, and chronic inflammation

F Sallusto et al. J Exp Med. .
No abstract available

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Figures

Figure 1
Figure 1
Mobilization and activation of DCs control the induction of tolerance, priming, and chronic inflammation. (A) Under steady state conditions, the recruitment of DC precursors into tissues and the migration of mature DCs to lymph nodes occur at low rates. Tissue antigens carried by short-lived migratory DCs may be transferred to resident lymphoid DCs that induce T cell tolerance. (B) Activated endothelial cells recruit DCs at higher rates. Immature DCs are attracted by inflammatory chemokines towards the site of inflammation, where bacterial and viral products induce DC maturation and activation. In the lymph node, activated T cells can further enhance DC activation and survival via CD40L and TRANCE. Because many and highly activated DCs are present, a productive T cell response is induced. (C) Mature DCs that fail to migrate to lymph nodes may serve as nucleation sites for chronic inflammatory reaction. Chemokines produced by these DCs attract maturing DCs as well as recently activated T cells, that maintain the inflammatory reaction. Thick lines indicate activated cells. Mo, monocytes; iDC, immature DCs; mDC, mature DCs; LyDC, lymphoid DCs.
See this image and copyright information in PMC

Comment on

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