Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1999 Jan 4;9(1):69-74.
doi: 10.1016/s0960-894x(98)00682-9.

Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region

C Shih  1 , L S Gossett, J M Gruber, C S Grossman, S L Andis, R M Schultz, J F Worzalla, T H Corbett, J T Metz
Affiliations

Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region

C Shih et al. Bioorg Med Chem Lett. .

Abstract

Structure modification of the beta-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (beta-alanine) with various (1)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.

PubMed Disclaimer

MeSH terms

LinkOut - more resources