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. 1976 Oct 1;159(1):177-80.
doi: 10.1042/bj1590177.

Alternative products in the reaction of 2-nitro-5-thiocyanatobenzoic acid with thiol groups

N C Price

Alternative products in the reaction of 2-nitro-5-thiocyanatobenzoic acid with thiol groups

N C Price. Biochem J. .

Abstract

2-Nitro-5-thiocyanatobenzoic acid has been proposed as a reagent for converting thiol groups in proteins into their S-cyano derivatives. Evidence was obtained for formation of both the S-cyano derivative and the mixed disulphide derivative. Formation of the S-cyano derivative can be promoted by addition of excess of CN-to the reaction mixture.

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